Which of the following describes a serious adverse effect associated with clindamycin?

Pseudomembranous colitis is a serious adverse effect associated with clindamycin due to its potential to disrupt the normal flora of the gastrointestinal tract. Clindamycin is an antibiotic that can lead to an overgrowth of Clostridium difficile, a bacteria known for causing severe gastrointestinal disturbances. This condition is characterized by inflammation and the formation of a pseudomembrane in the colon, which can cause symptoms such as severe diarrhea, abdominal pain, and fever. It is crucial for healthcare providers to monitor patients taking clindamycin for signs of this condition, as it can lead to life-threatening complications if not addressed promptly.

Other adverse effects like anaphylaxis, blood dyscrasias, and rash can occur with clindamycin use; however, they are generally considered less common or less severe compared to pseudomembranous colitis. While anaphylaxis is a serious allergic reaction, it occurs rarely in comparison to the incidence of pseudomembranous colitis linked to clindamycin use. Blood dyscrasias can develop with numerous drugs and are not specifically associated with this antibiotic. Rash also represents a spectrum of skin reactions that, while concerning, are not on the same level of severity as